Effects of Mitochondria and O-Methoxybenzoylalanine on 3-Hydroxyanthranilic Acid Dioxygenase Activity and Quinolinic Acid Synthesis
نویسندگان
چکیده
منابع مشابه
Quinolinic acid accumulation in the conversion of 3-hydroxyanthranilic acid to niacin in Neurospora.
3-Hydroxyanthranilic acid has been shown to serve as a natural precursor of niacin in Neurospora. 12 Little. information, however, has been obtained concerning the mechanism whereby the aromatic ring of 3hydroxyanthranilic acid is converted to the pyridine ring of niacin. The present paper will deal with this latter problem. Singal, et al.,I have reported that the administration of tryptophan t...
متن کاملQuinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region.
Quinolinic acid (QUIN) is a potent endogenous excitotoxin, which has been shown to be present in the brain (Wolfensberger et al., 1983). In order to study the cellular localization of QUIN metabolism in the hippocampus, specific antibodies raised against purified rat liver 3-hydroxyanthranilic acid oxygenase (3HAO) and quinolinic acid phosphoribosyltransferase (QPRT), the enzymes directly respo...
متن کامل3-hydroxyanthranilic Acid Metabolism
The participation of 3-hydroxyanthranilic acid as an intermediate in the biosynthesis of nicotinic acid from tryptophan was first demonstrated in certain mutant strains of Neurospora in 1948 by Bonner (1) and by Mitchell and Nyc (2). In addition, Mitchell et al. (3) found that 3-hydroxyanthranilic acid can replace nicotinic acid in the nutrition of the rat. In 1946 Singal et al. (4) noted a sub...
متن کاملhistological evaluation of the effect of three medicaments; trichloracetic acid, formocresol and mineral trioxide aggregate on pulpotomized teeth of dogs
چکیده ندارد.
15 صفحه اولStudies on purified 3-hydroxyanthranilic acid oxidase.
3-Hydroxyanthranilic acid oxidase is known to cat,alyze the oxidation of 3-hydroxyanthranilic acid to a very unstable aliphatic compound, which may either be spontaneously transformed into quinolinic acid or undergo enzymic conversion to picolinic or nicotinic acid, or both (l-3). According to Mason (4), this enzyme has been classified as an “oxygen transferase,” since the oxygen consumed, 1 mo...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2008
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.1999.0721125.x